GWAS, CAD, corangiogen, resources, links

ECHOCARDIOGRAPHY VASAN 2009 JAMA

In stage 1, 16 genetic loci were associated with 5 echocardiographic traits: 1 each with LV internal dimensions and systolic dysfunction, 3 each with LV mass and wall thickness, and 8 with aortic root size. In stage 2, 5 loci replicated (6q22 locus associated with LV diastolic dimensions, explaining <1% of trait variance; 5q23, 12p12, 12q14, and 17p13 associated with aortic root size, explaining 1%-3% of trait variance).

CHARGE CONSORTIUM

prospective meta-analysis HEART FAILURE  SMITH 2010

MORTALITY Morrison 2010  (1 snp  1 genome-wide significant locus on chromosome 3p22 in an intron of CKLF-like MARVEL transmembrane domain containing 7 (CMTM7


gwas of CAD/ MI
Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease.

Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.
2009

RESULTS: Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22-1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.

Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosis  MUENDLEIN DREXEL 2009


Mechanisms of Disease: the genetic basis of coronary heart disease kULLO 2007 Nature...

cf CHARGE
Design of the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) Study -- A Genome-Wide Association Meta-Analysis Involving More than 22,000 Cases and 60,000 Controls.