Bioinformatics Research Group - University of Patras - FINDbase-PGx

Bioinformatics Research Group - University of Patras - FINDbase-PGx: "FINDbase-PGX"

pharmacogenomics database, based on published articles
- ? what information can I get from that
- allele frequencies by population, by pharmacogenomic study
- ???


check other databases by U Patras
- FINDbase
- HELPIDA - spatial epidemiology

cf checkout SOFTWARE microsoft pivot viewer, silverlight.

epidemiology, clinical trials

last observation carried forward (LOCF)- dropout
intention to treat ITT
as treated
per protocol

wiki

Publikácie

Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes.
PDF - early online,Z. Schroner, M. Javorsky, R. Tkacova2, L. Klimcakova, M. Dobrikova, V. Habalova, M.Kozarova, J. Zidzik, M. Rudikova & I. Tkac.

Pubmed
This is an Accepted Article that has been peer_reviewed and approved for publication in the Diabetes, Obesity and Metabolism, but has yet to undergo copy_editing and proof correction. Please cite this article as an "Accepted Article"; doi: 10.1111/j.1463-1326.2010.01324.x 

ENDOKRINNÁ FUNKCIA TUKOVÉHO TKANIVAhttp://www.solen.sk/index.php?page=pdf_view&pdf_id=3061&magazine_id=1


http://ciselniky.dasta.mzcr.cz/cd_ds4/hypertext/AJFBZ.htm

štatistika v Exceli

http://phoenix.phys.clemson.edu/tutorials/excel/stats.html

Grubbsov test - extrémne (odľahlé) hodnoty - vysvetlenie na stránke Graphpad (EN) !!!!


Dixonov test - outliers (EN) - thread
na identifikáciu JEDNEJ odľahlej/extrémnej hodnoty v súbore
1. zoraď hodnoty podľa veľkosti
2. odľahlé (extrémne) hodnoty na hornom/dolnom konci??? príliš vysoká, príliš nízka??
koeficient (pomer) Q (rozdiel medzi "podozrivou" hodnotou a najbližšou hodnotou) / (rozsah hodnôt t.j. max - min)
3. porovnaj hodnotu pomeru s hodnotou kritickou. (ak vypočítaná hodnota Q > Q_critical tpotom danú hodnotu možno považovať za odľahlú/extrémnu)

(modifikácie dixonovho testu v závislosti od počtu subjektov v štúdii - vid Verma2006, page from Goettingen)

kritické hodnoty pre Dixonov test Verma 2006
Goettingen Grubbs et Dixon

Stats in chemistry (calibration etc). simple explanation of Grubbs test, Dixon test



educational applets  Dixon test  ( page by greeek prof)
student T test - demo + online calculator
online štatistické kalkulátory
SOCR - JAVA based
GRAPHPAD http://www.graphpad.com/quickcalcs/index.cfm

guide to statistical test interpretation graphpad prism XXX

štatistika po slovensky

základy, terminologia

pharmacogenomics, textmining

http://www.ncbi.nlm.nih.gov/pubmed/21121063?dopt=Abstract
cf related

informed consent for genomics research

informed consent for genomics research - from the National Human Genome Research institute

biobank at Karolinska Institutet


Protocol construction resources: standardized

PhenX Toolkit

OpenClinica Library - based on CDISC standard

CDISC , form builder - nice but complicated, CDE browser

CDISC is an open, multidisciplinary, non-profit organization committed to the development of industry standards to support the electronic acquisition, exchange, submission, and archiving of clinical trials data and metadata for medical and biopharmaceutical product development.

CDISC - LAB MODEL

the science, the ideas, Hillis, cancer, proteomics

cancering  proteomics
interview with Daniel Hillis
Edge website !!!

http://www.edge.org/
- interesting site, including question center, ...

long now website: perspective of 10,000 years - long term and responsible thinking